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Project Overview

Problem:

  • Most cancer patients who enroll in clinical trials learn of these opportunities from their providers or from study staff, but most hospitals do not run trials.
  • Existing patient-facing tools for clinical trial matching typically require a challenging amount of manual clinical data entry and / or manual review of trials.
  • Providers do not have tools built in their workflow to allow for efficient clinical trial matching. As a result, providers often have to use the same patient-facing tools and manually enter data and / or manually review trials. 

Description: 

  • A cancer patient identifies clinical trials for which she may be eligible. She uses tools that she can access directly, and she does not have to do manual transcription of clinical data. Rather, the patient facing matching tools leverage structured patient data from the electronic health record (EHR) to assess clinical trial eligibility. 
  • A provider identifies clinical trials for which her patient may be eligible. She uses tools that she can access directly in her workflow and does not have to do manual transcription of clinical data. Rather, there is a tool built into the EHR system that allows the provider to send structured patient data straight from the EHR to a matching service to assess potential matches. 

Target Outcome:

  • Develop open data standards and open APIs that enable interoperable, scalable, and accessible clinical trial matching services
    • Drive awareness of and commitment to use these standards in the industry
    • Thereby improve clinical trial matching for patients and their care teams

Value: 

  • Patients and providers will be able to find lifesaving clinical trials much easier and faster.
  • Matching services will be able to receive more accurate, complete, structured, and computable patient data using mCODE and will be able to narrow down a more accurate list of potential clinical trials. 
  • Patient portals will be able to easily send data to matching services and will be able to present clinical trial matches back to their clients. 
  • EHR vendors will be able to enable a service that will help their clients treat patients.
  • Pharmaceutical companies will be able to find more patients for their clinical trials to discover new drugs. 



Project Plan

Data Sources: Phase 0



Phase 0: Standards Development (in progress) 

  • The goal of this phase is to create a proof-of-concept that demonstrates the ability of a trial matching service to receive an mCODE record, analyze the record to make matches, and then present the matches back to the patient or provider. 
  • Standards and documentation are created to allow for other matching services and patient portals to implement this capability.
    • The GitHub Code Repository's can be found in the "Quick Links" section. 
  • If you'd like to see a demo, please contact Salim Semy or Caroline Potteiger. Contact information is listed below.  

Phase 1: Retrospective Study

  • The goal of this phase is to complete a retrospective study in which past patient records are sent to multiple matching services that have enabled mCODE.
  • This demonstrates that multiple matching services can be mCODE-enabled and will determine if the minimal eligibility criteria currently used is sufficient to support patient clinical trial matching. 

Phase 2: Prospective Study 

  • The goal of this phase is to complete a prospective study in which current patient records are sent to multiple matching services that have enabled mCODE. 
  • This demonstrates the value of mCODE-enabled clinical trial matching services and the improved ease of finding clinical trials for patients when a matching service is mCODE enabled.

Current Partners 

  • American Cancer Society Cancer Action Network (ACS CAN) (co-champion)
  • The MITRE Corporation (co-champion)
  • TrialScope (matching service)
  • Cancer Insights (patient portal)
  • Breastcancertrials.org (matching service) 




Conference Call Information

The Integrated Trial Matching for Cancer Patients and Providers project team meets weekly on Friday at 12:30pm ET. If you'd like to join the call, please contact Caroline Potteiger. 

A call open to the public will be occurring soon. Please stay tuned for more information. 


Meeting Notes

DateNotes
June 19th, 2020 Meeting Notes
June 12th, 2020 Meeting Notes
June 5th, 2020 Meeting Notes

Notes from the last three meetings are listed here. If you'd like to see notes from further in the past, please navigate to the Trial Matching Meetings page. 

Use Case Team

RoleNameOrganizationEmail
ChampionMark FleuryAmerican Cancer Society Cancer Action Networkmark.fleury@cancer.org
ChampionKelly DurdenAmerican Cancer Society Cancer Action Networkkelly.durden@cancer.org
Use Case LeadSalim SemyThe MITRE Corporation

ssemy@mitre.org 

Use Case LeadCaroline PotteigerThe MITRE Corporation

cpotteiger@mitre.org 

Technical LeadZach ListerThe MITRE Corporation zlister@mitre.org
Patient Portal Tarun KumarCancer Insights tarun@vizlitics.com
Patient Portal Shilpa MahatmaCancer Insights shilpa@vizlitics.com
Matching Service Mike WengerTrialScopeMike.Wenger@trialscope.com
Matching ServiceElly CohenBreastcancertrials.orgElly.Cohen@ucsf.edu
Matching ServiceSuresh GadamsettyBreastcancertrials.orgsuresh.gadamsetty@quantumleaphealth.org