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Project Overview

Problem:

  • Most cancer patients who enroll in clinical trials learn of these opportunities from their providers or from study staff, but most hospitals do not run trials.
  • Existing patient-facing tools for clinical trial matching typically require a challenging amount of manual clinical data entry and / or manual review of trials.
  • Providers do not have tools built in their workflow to allow for efficient clinical trial matching. As a result, providers often have to use the same patient-facing tools and manually enter data and / or manually review trials. 

Description: 

  • A cancer patient identifies clinical trials for which she may be eligible. She uses tools that she can access directly, and she does not have to do manual transcription of clinical data. Rather, the patient facing matching tools leverage structured patient data from the electronic health record (EHR) to assess clinical trial eligibility. 
  • A provider identifies clinical trials for which her patient may be eligible. She uses tools that she can access directly in her workflow and does not have to do manual transcription of clinical data. Rather, there is a tool built into the EHR system that allows the provider to send structured patient data straight from the EHR to a matching service to assess potential matches. 

Target Outcome:

  • Create integrated, automated, site-agnostic clinical trial matching by developing open data standards and open APIs that enable interoperable, scalable, and accessible clinical trial matching services
    • Drive awareness of and commitment to use these standards in the industry
    • Thereby improve clinical trial matching for patients and their care teams

Value: 

  • Patients and providers can easily identify potentially lifesaving therapies much faster with tools that leverage structured data from the EHR.
  • Matching services will be able to receive more accurate, complete, structured, and computable patient data using mCODE and will be able to narrow down a more accurate list of potential clinical trials. 
  • Patient portals will be able to easily send data to matching services and will be able to present clinical trial matches back to their clients. 
  • EHR vendors will be able to enable a service that will help their clients treat patients.
  • Researchers can find more patients for their clinical trials. 




Project Plan

Phase

Milestone

Timeline

DiscoveryUse case identification 

COMPLETE

Planning

Plan out high level project plan, deliverables, success measures, high level timeline, key stakeholders, etc

COMPLETE

Phase 0 Demonstrate the ability of a trial matching service to receive an mCODE record, analyze the record to make matches, and then present the matches back to the patient or provider
Phase 1

Send past patient records to multiple mCODE-enabled trial matching services to demonstrate multiple matching services can become mCODE-enabled and evaluate the effectiveness of the optimized patient data elements. 

Phase 2

Send current patient records to multiple mCODE-enabled trial matching services to demonstrate the value of mCODE-enabled clinical trial matching services and the improved ease of finding clinical trials for patients when a matching service is mCODE enabled.

Launch pilot fall 2022

Conference Call Information

The Integrated Trial Matching for Cancer Patients and Providers project team meets every other week on Friday at 12:30pm ET. The weekly call minutes are available on the Trial Matching Meetings page. 




Use Case Team

RoleNameOrganization
ChampionMark FleuryAmerican Cancer Society Cancer Action Network
ChampionDevon AdamsAmerican Cancer Society Cancer Action Network
Use Case CoordinatorSalim SemyThe MITRE Corporation
Use Case CoordinatorCaroline PotteigerThe MITRE Corporation
Technical CoordinatorZach ListerThe MITRE Corporation 
Patient Portal Tarun KumarCancer Insights 
Patient PortalSharon Hensley AlfordCancer Insights 
Patient PortalDebi WillisPatientLink
Matching Service Mike WengerTrialScope
Matching ServiceElly CohenBreastcancertrials.org
Matching ServiceTzvia Bader TrialJectory 
Health SiteMelanie HullingsUniversity of Texas Southwestern 
Health Site Waddah ArafatUniversity of Texas Southwestern 
FunderJude NgangAmgen
FunderJeanette SchulzAmgen

If you'd like to learn more about this use case, please contact Caroline Potteiger - cpotteiger@mitre.org 

Current Partners 

  • American Cancer Society Cancer Action Network (ACS CAN) (co-champion)
  • Amgen (funder)
  • Breastcancertrials.org (matching service) 
  • Cancer Insights (patient portal)
  • The MITRE Corporation (co-champion)
  • PatientLink (patient portal)
  • TrialJectory (matching service)
  • TrialScope (matching service)
  • The University of Texas Southwestern (health system) 











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