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This page captures the initial response to C-CDA STU comment 2034 to replace NDF-RT Drug Classes with SNOMED in Value Set Substance Reactant for Intolerance:2.16.840.1.113762.1.4.1010.1

The ONC published USCDI version 1 which requires SNOMED CT for Substance (Drug Class), and the ONC ISA references Product Hierarchy.

The initial concepts included will be built based on prevalence of substance class as defined by the HL7 Cross Paradigm Specification: Allergy and Intolerance Substance Value Set(s) Definition, Release 1

The value set created in VSAC with these concepts is Medication drug class for allergen intolerance SCT2.16.840.1.113762.1.4.1114.14. This value set includes all the concepts in the "Product hierarchy code" column plus the one Substance hierarchy code for Iodinated contrast media (substance). That specific updated value set can be viewed here. The grouping value set that includes this updated drug class member value set is here.

FHIR Issue for alignment of USCore content is  FHIR-29322 - Getting issue details... STATUS

Please use the comments below to discuss concerns.  

Green cells are concepts that have links in NLM RxClass that can be used in RxMix to identify RxNorm class-based list of clinical drugs. Non-colored cells, mostly, may not benefit from the missing link. For those that we need better linkage, wee will ask NLM for support. Please comment to indicate where additional support would be useful.

Concept Name

Substance hierarchy Code

Product hierarchy Code

System

Counts

Fraction

Penicillin -class of antibiotic- (substance)

373270004

6369005

SNOMED CT

5127642

14.37%

Sulfonamide (substance)

387406002

763875007

SNOMED CT

2327334

6.52%

Adhesive agent (substance)

418920007

788032009

SNOMED CT

461297

1.29%

Iodinated contrast media (substance)

426722004

Nothing Available - use 426722004

SNOMED CT

268938

0.75%

Non-steroidal anti-inflammatory agent (substance)

372665008

16403005

SNOMED CT

253652

0.71%

Contrast media (substance)

385420005

407935004

SNOMED CT

220629

0.62%

Opiate agonist (substance)

404642006

360204007

SNOMED CT

169832

0.48%

Cephalosporin -class of antibiotic- (substance)

373262009

764299009

SNOMED CT

161316

0.45%

Angiotensin-converting enzyme inhibitor agent (substance)

372733002

41549009

SNOMED CT

161076

0.45%

Tetanus vaccine (substance)

412375000

871742003

SNOMED CT

130964

0.37%

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (substance)

372912004

96302009

SNOMED CT

93174

0.26%

Influenza virus vaccine (substance)

396425006

1181000221105

SNOMED CT

87077

0.24%

Quinolone -class of antibiotic- (substance)

372722000

37084008

SNOMED CT

86159

0.24%

Tetracycline (class of antibiotic, substance) (substance)

373206009

282831004

SNOMED CT

69249

0.19%

Sulfonylurea (substance)

372711004

34012005

SNOMED CT

61194

0.17%

beta-Blocking agent (substance)

373254001

33252009

SNOMED CT

31911

0.09%

Pneumococcal vaccine (substance)

398730001

836398006, 1801000221105, 981000221107

SNOMED CT

22746

0.06%

Antihistamine (substance)

372806008

6425004

SNOMED CT

20015

0.06%

Diphtheria + tetanus vaccine (product)

350327004

871826000

SNOMED CT

16884

0.05%

Corticosteroids and derivatives (substance)

304275008

79440004

SNOMED CT

12898

0.04%








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